Postdoctoral Researcher (m/f/d)
Engineering the Next Generation of In Vivo CAR-T Cell Therapies with CRISPR 2.0
- Universitätsklinikum Würzburg
- 01.01.2027
- Vollzeit
- befristet
Application deadline: 31/10/2026
Wir bieten
- Scientific leadership in a newly funded ERC project
Take a central role in establishing new technologies and shaping the scientific direction of an ambitious research program from an early stage. - Cutting-edge interdisciplinary research
Work at the interface of CRISPR 2.0 technologies, lipid nanoparticle delivery, immune-cell engineering, and translational cell therapy. - Scientific independence and creative freedom
Develop and pursue your own scientific ideas within a framework designed to support high-risk, high-gain research. - Access to state-of-the-art technologies
Utilize advanced genome-engineering tools, delivery platforms, molecular and cellular biology methods, and immunological assays. - International visibility and networking opportunities
Present your work at international conferences, establish collaborations, and contribute to the development of internationally competitive technologies. - Mentoring and career development
Supervise junior researchers, strengthen your leadership skills, and build a strong foundation for future careers in academia, biotechnology, or pharmaceutical R&D.
Key Research Areas
- CRISPR 2.0 and next-generation genome engineering
- Lipid nanoparticle (LNP)-based delivery systems
- In vivo genome editing and cell engineering
- CAR-T cell and immune-cell engineering
- Synthetic immunology
- Molecular and cellular biology
- Translational cancer immunotherapy
- Non-viral and targeted delivery technologies
Ihr Aufgabengebiet
- Develop and optimize next-generation CRISPR genome-engineering approaches for immune-cell engineering
- Design and evaluate innovative strategies for the generation of CAR-T cells directly in vivo
- Develop and characterize viral and non-viral delivery platforms, including lipid nanoparticle-based systems
- Establish new experimental technologies and workflows within the laboratory
- Assess genome-editing efficiency, specificity, safety, and functional outcomes
- Perform molecular, cellular, and immunological characterization of engineered immune cells
- Contribute to project design, scientific strategy, and technology development
- Supervise PhD students and junior researchers
- Establish interdisciplinary collaborations and contribute to scientific publications, grant applications, and conference presentations
The project
CAR-T cell therapy has transformed the treatment of selected hematological malignancies, but current approaches depend on complex, costly, and time-consuming ex vivo manufacturing.
Our ERC project aims to explore a fundamentally different paradigm: direct engineering of therapeutic immune cells in vivo.
To achieve this, we will combine next-generation genome-editing technologies with innovative concepts in immune-cell engineering and targeted delivery, with a particular interest in lipid nanoparticle-based approaches. A major focus will be on CRISPR 2.0 technologies that expand the possibilities of genome engineering beyond conventional DNA double-strand-break-based editing.
The successful candidate will play a central role in developing and translating these concepts into new strategies for the precise generation of CAR-T cells in vivo, including the development and evaluation of delivery strategies for genome-editing components.
Ihr Profil
We are looking for a creative, highly motivated scientist who enjoys developing new technologies and tackling ambitious biological questions.
Applicants should have:
- A PhD in molecular biology, biomedicine, biotechnology, biochemistry, immunology, pharmaceutical sciences, nanomedicine, or a related discipline
- A strong background in molecular and cellular biology, genome engineering, drug delivery, or nanomedicine
- Experience in genome engineering, CAR-T cells or lipid nanoparticles
- A strong interest in developing and applying next-generation CRISPR and delivery technologies
- The ability to independently design, conduct, analyze, and troubleshoot experiments
- A collaborative mindset and enthusiasm for interdisciplinary research
- Excellent communication skills in English
Experience with lipid nanoparticle formulation and characterization, targeted LNP delivery, primary human T cells, CRISPR-based genome editing, CAR-T cells, flow cytometry, or other viral or non-viral delivery technologies would be particularly valuable.
Importantly, we do not expect candidates to already be experts in all aspects of the project. Previous experience with lipid nanoparticles is a strong plus, but not a prerequisite. We are looking for scientists with a strong experimental foundation, intellectual curiosity, and the ambition to expand into new technological areas.
Darauf können Sie sich freuen
- Anspruchsvolles, vielfältiges und entwicklungsfähiges Aufgabengebiet
- Attraktive Bezahlung nach TV-L inkl. Jahressonderzahlung
- Aus- und Weiterbildung in der eigenen Akademie
- Betriebliche Altersvorsorge
- Betriebskindertagesstätte mit verlängerten Öffnungszeiten
- Betriebssportangebote
- Flexible Arbeitszeiten dank Gleitzeitregelung
- Jobrad
- Mitarbeiter Angebote
Werden Sie Teil des Teams: Jetzt bewerben!
Emmy Noether Gruppenleiter
Tel: +49931 201 44817
Die Vergütung erfolgt nach den einschlägigen Tarifverträgen. Schwerbehinderte Bewerber/-innen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt eingestellt.