PhD Position (m/f/d)
in Megakaryocyte Biology

Application deadline: 15/12/2024

The University Hospital Würzburg is seeking a motivated and talented PhD student (m/f/d) to join the Emmy Noether Research Group led by Dr. Zoltan Nagy at the Institute of Experimental Biomedicine. Be part of a dynamic research group and investigate fundamental mechanisms in hematology!

In this DFG-funded project, you will work at the forefront of megakaryocyte biology, leveraging state-of-the-art technologies, including single-cell transcriptomics, CRISPR gene editing, transgenic mouse models, and advanced imaging techniques.

• You will have access to cutting-edge laboratory facilities, including single-cell platforms, high-resolution imaging systems, and automated immunoblotting technologies.
• You will contribute to an exciting research project based on a recently discovered signalling pathway crucial for megakaryocyte maturation.
• You will receive comprehensive training in molecular, cellular, and data analysis methods.
• We offer personalized mentoring and a collaborative environment designed to support your professional growth.

• Design and perform single-cell RNA sequencing experiments, applying advanced data analysis to identify novel regulatory mechanisms.
• Conduct in vivo studies in mouse models, focusing on experimental hematology techniques to investigate and modulate platelet biogenesis.
• Carry out in vitro cell culture experiments, utilizing stem cell differentiation protocols and CRISPR-based gene editing to manipulate and study megakaryocyte function.
• Perform innovative biochemical experiments, including advanced immunoblotting, to dissect key signalling pathways involved in megakaryocyte development.
• Present research findings at project meetings and conferences, and contribute to peer-reviewed publications.

• A Master’s degree in Biochemistry, Cell Biology, Molecular Biology, Hematology, or a related field.
• A strong foundation in molecular and cellular biology, with hands-on experience in cell culture and techniques such as microscopy, flow cytometry, or Western blotting.
• Interest in bioinformatics, including single-cell RNA-seq data analysis, and computational skills, such as experience with data analysis tools (e.g., GraphPad) or programming languages like R, would be an advantage.
• Demonstrated scientific rigor, curiosity, and a willingness to learn and apply new methods.
• Strong motivation and communication skills, with proficiency in written and spoken English demonstrated through a language exam, thesis work, publications, or conference presentations.

• Training and Continuing Education
• Retirement Pension Plan
• Flexible Working Hours
• Collegiality
• Sport and Fitness Options
• Employee Events
• Corporate Benefits

In the case of a university degree from a non-EU country, a long version of the certificate evaluation from the Central Office for Foreign Education is required.

Remuneration is in accordance with the relevant collective agreements. Severely disabled applicants will be given preference if they are otherwise equally qualified.

The University Hospital of Würzburg (UKW) offers an innovative and excellent working environment in cutting-edge medicine. Here, employees benefit from state-of-the-art technology, extensive training and career opportunities as well as flexible working time models for an optimal work-life balance. We attach great importance to diversity and inclusion in order to create a respectful and supportive working environment. A strong sense of community and interdisciplinary collaboration are central to our way of working. Würzburg, a city with a high quality of life, offers a wide range of cultural and leisure activities as well as excellent educational opportunities. The UKW takes responsibility for the health of society and promotes an environment that focuses on ethical values and social commitment. Become part of our team and help shape the future of medicine.